What is the chemical structure of (2E)-3-(2,5-Difluorophenyl)acrylic acid, trans-3-(2,5-Difluorophenyl)prop-2-enoic acid?

(2E)-3-(2,5-Difluorophenyl)acrylic acid, also known as trans -3-(2,5-Difluorophenyl)prop-2-enoic acid, has a specific chemical structure.
The base structure of this compound is acrylic acid.Acrylic acid is the base structure of this chemical compound. Acrylic acid consists of a two - carbon double - bond (C = C) with a carboxylic acid group (-COOH) attached to one of the carbon atoms in the double - bond.Acrylic acid is a double-carbon bond (C=C) with a carboxylic group (-COOH), attached to one carbon atom. So, we have the structure CH2=CH - COOH as the basic acrylic acid framework.We have the basic acrylic acid structure CH2=CH-COOH.

Now, for (2E)-3-(2,5 - Difluorophenyl)acrylic acid, the "3 - (2,5 - Difluorophenyl)" part indicates that a phenyl ring with fluorine atoms at the 2 - and 5 - positions is attached to the third carbon of the acrylic acid structure.

The phenyl ring is a six - membered aromatic ring composed of carbon atoms with alternating single and double bonds.The phenyl group is a six-membered aromatic ring made up of carbon atoms alternating between single and double bonds. In the 2,5 - difluorophenyl group, two fluorine atoms are attached to the phenyl ring.In the 2,5-difluorophenyl groups, two fluorine molecules are attached to phenyl rings. One fluorine atom is bonded to the carbon atom which is numbered 2 in the phenyl ring's numbering system, and the other fluorine atom is bonded to the carbon atom numbered 5.One fluorine is bonded with the carbon atom that is numbered 2, in the numbering system of the phenyl rings, and the second fluorine is bonded with the carbon 5 atom.

This phenyl group is then connected to the carbon atom in the acrylic acid structure that is farthest from the carboxylic acid group.The phenyl group in the acrylic acid is then connected to that carbon atom which is the furthest away from the carboxylic group. The "E" in (2E) indicates the configuration around the double bond.The "E" in the (2E) indicates that the double bond is arranged around it. In the E configuration, the higher - priority groups are on opposite sides of the double bond.In the E configuration, higher - priority group are on the opposite side of the double bond. Here, the phenyl group and the carboxylic acid group are the higher - priority groups, and they are arranged in a trans - like fashion with respect to the double bond.The phenyl and carboxylic groups are the higher-priority groups and are arranged trans-like with respect to double bond.

So, in summary, the chemical structure of (2E)-3-(2,5 - Difluorophenyl)acrylic acid has an acrylic acid backbone where one of the hydrogens on the carbon atom farthest from the carboxylic acid group is replaced by a 2,5 - difluorophenyl group, and the double bond has an E - configuration, ensuring the proper spatial arrangement of the phenyl and carboxylic acid groups. This structure gives the compound its unique chemical and physical properties, which can be significant in various chemical reactions, pharmaceutical applications, or materials science studies where this compound might be used.This structure gives this compound its unique physical and chemical properties. These properties can be important in various chemical reactions, pharmaceuticals, or materials science experiments where the compound may be used.

What are the applications of (2E)-3-(2,5-Difluorophenyl)acrylic acid, trans-3-(2,5-Difluorophenyl)prop-2-enoic acid?

(2E)-3-(2,5-Difluorophenyl)acrylic acid, also known as trans-3-(2,5-Difluorophenyl)prop-2-enoic acid, has several important applications.
One of the main areas of application is in the field of pharmaceuticals.Pharmaceuticals is one of the most important areas of application. Compounds with a similar structure often exhibit biological activities.Compounds of similar structure are often biologically active. This particular acid can potentially serve as a key intermediate in the synthesis of drugs.This acid could be used as a key ingredient in the synthesis or drugs. For example, it may be used to create molecules that target specific biological pathways.It can be used to create molecules which target specific biological pathways. Its fluorine - containing phenyl group can influence the lipophilicity and binding properties of the final drug product.The fluorine-containing phenyl groups in the phenyl group of the drug can affect the binding and lipophilicity properties. This can enhance the drug's ability to penetrate cell membranes and bind to target receptors more effectively.This can improve the drug's ability of binding to receptors and to penetrate cell membranes. It could be involved in the development of drugs for treating various diseases such as inflammatory disorders, where molecules with specific binding and anti - inflammatory properties are needed.It could be used in the development and testing of drugs to treat various diseases, such as inflammatory disorders.

In the agrochemical industry, it can play a role in the production of pesticides or herbicides.In the agrochemical sector, it can be used to produce pesticides and herbicides. The unique structure of the acid can be modified to create compounds that have a high affinity for certain pests or unwanted plant species.The unique structure of this acid can be altered to create compounds with a high affinity towards certain pests or unwanted plants. The fluorine atoms can contribute to the compound's stability and its ability to interact with the biological systems of the target organisms.The fluorine atoms in the compound can enhance its stability and ability to interact with biological systems of target organisms. This might lead to the development of more effective and environmentally friendly agrochemicals with reduced toxicity to non - target organisms.This could lead to the development more environmentally friendly and effective agrochemicals that are less toxic to non-target organisms.

The chemical synthesis field also benefits from this compound.This compound is also useful in the field of chemical synthesis. It serves as a valuable building block for the construction of more complex organic molecules.It is a useful building block to construct more complex organic molecules. Chemists can utilize its double bond and carboxylic acid functional groups for a variety of reactions.Chemists use its carboxylic acid and double bond functional groups in a variety reactions. For instance, the double bond can be used in Diels - Alder reactions to form cyclic structures.Double bonds can be used to create cyclic structures in Diels-Alder reactions. The carboxylic acid group can be transformed into esters, amides, or other derivatives, enabling the creation of a diverse range of chemical products.The carboxylic group can be converted into esters, amino acids, or other derivatives. This allows for a wide range of chemical products to be created.

In materials science, derivatives of (2E)-3-(2,5 - Difluorophenyl)acrylic acid could potentially be used to develop new polymers. The incorporation of the fluorinated phenyl moiety into a polymer backbone can modify the polymer's properties.The incorporation into the polymer backbone of the fluorinated-phenyl moiety can alter the polymer properties. It might increase the polymer's resistance to degradation, improve its thermal stability, or alter its optical properties.It could increase the polymer’s resistance to degradation or improve its thermal stability. These modified polymers could then be used in applications such as coatings, where enhanced durability and chemical resistance are required.These modified polymers can then be used for applications such as coatings where durability and chemical resistance is required.

What are the properties of (2E)-3-(2,5-Difluorophenyl)acrylic acid, trans-3-(2,5-Difluorophenyl)prop-2-enoic acid?

(2E)-3-(2,5 - Difluorophenyl)acrylic acid, also known as trans - 3-(2,5 - Difluorophenyl)prop - 2 - enoic acid, has several important properties.
Firstly, in terms of its chemical structure, it contains a phenyl ring with two fluorine atoms at the 2 and 5 positions, and an acrylic acid moiety.It contains an acrylic acid moiety and a phenyl-ring with two fluorine molecules at the 2nd and 5th positions. The presence of the fluorine atoms on the phenyl ring imparts unique electronic and steric effects.The presence of fluorine on the phenyl rings imparts unique electronic effects and steric properties. Fluorine is highly electronegative, which can influence the reactivity of the molecule.Fluorine has a high electronegative charge, which can affect the reactivity. It can withdraw electron density from the phenyl ring, affecting the electron distribution in the entire molecule and potentially altering its reactivity towards electrophiles and nucleophiles.It can remove electron density from the phenyl rings, altering the electron distribution throughout the entire molecule.

Regarding its physical properties, it is likely to be a solid at room temperature.It is likely that it will be a solid when it comes to its physical properties. Compounds with similar structures often have relatively high melting points due to intermolecular forces such as hydrogen bonding, which can occur through the carboxylic acid group.Compounds that have similar structures are often characterized by high melting points, due to intermolecular interactions such as hydrogen bonds. The carboxylic acid group (-COOH) can form hydrogen bonds with other molecules of the same compound or with suitable solvents.The carboxylic group (-COOH), can form hydrogen bonding with other molecules in the same compound, or with suitable solvents. This can also influence its solubility properties.This can also affect its solubility. It may have some solubility in polar solvents like water, alcohols, and carboxylic acids due to the ability of the carboxylic acid group to interact with polar solvents through hydrogen bonding.It may be soluble in polar solvents such as water, alcohols and carboxylics due to the ability for the carboxylic group to interact with the polar solvents via hydrogen bonding. However, the presence of the non - polar phenyl ring may limit its solubility in highly polar solvents and increase its solubility in less polar organic solvents such as ethers or chloroform.The presence of a non-polar phenyl group may limit its solubility with highly polar solvents, but increase its solubility with less polar organic solutions such as ethers and chloroform.

In terms of chemical reactivity, the double bond in the acrylic acid part of the molecule is a site of high reactivity.The double bond in the part of the acrylic acid molecule that is high-reactive chemically. It can undergo addition reactions.It can undergo addition reaction. For example, it can react with electrophiles such as bromine or hydrogen halides in electrophilic addition reactions.It can, for example, react with electrophiles like bromine or hydrohalides in electrophilic reactions. The double bond can also participate in polymerization reactions, especially under appropriate conditions and in the presence of suitable initiators.Double bonds can also be involved in polymerization, particularly under the right conditions and with the right initiators. The carboxylic acid group can undergo typical reactions of carboxylic acids.The carboxylic group can undergo the typical reactions of carboxylics. It can be esterified with alcohols in the presence of an acid catalyst to form esters.It can be esterified in the presence an acid catalyst with alcohols to form esters. It can also react with bases to form salts.It can also react to form salts with bases. Additionally, the presence of the fluorinated phenyl ring can influence the regioselectivity of these reactions, as the fluorine atoms can direct the incoming reagents to specific positions on the molecule.The presence of a fluorinated phenyl can also influence the regioselectivity in these reactions. Fluorine atoms are able to direct the incoming reagents towards specific positions on the molecules.

Overall, (2E)-3-(2,5 - Difluorophenyl)acrylic acid has a combination of physical and chemical properties that are determined by its unique molecular structure, with the fluorinated phenyl ring and acrylic acid moiety playing crucial roles in dictating its behavior.

What is the synthesis method of (2E)-3-(2,5-Difluorophenyl)acrylic acid, trans-3-(2,5-Difluorophenyl)prop-2-enoic acid?

Here is a common synthesis method for (2E)-3-(2,5 - Difluorophenyl)acrylic acid (trans - 3-(2,5 - Difluorophenyl)prop - 2 - enoic acid).
1. Starting materials preparationStart materials preparation
The synthesis often starts with 2,5 - difluorobenzaldehyde. This compound can be obtained through multi - step reactions from commercially available starting materials.This compound can be produced by multi-step reactions using commercially available starting material. For example, it can be synthesized from 2,5 - difluorotoluene via oxidation of the methyl group to an aldehyde group.It can be made from 2,5-difluorotoluene by oxidizing the methyl group into an aldehyde. Another important starting material is a reagent that can provide the acrylic acid moiety.A reagent which can provide the acrylic-acid moiety is another important starting material. Malonic acid is a frequently used compound for this purpose.This is often done with malonic acid.

2. Knoevenagel condensation reaction
The key step in the synthesis is the Knoevenagel condensation.The Knoevenagel condensation is the key step in the syntheses. In this reaction, 2,5 - difluorobenzaldehyde reacts with malonic acid in the presence of a base catalyst.In this reaction, malonic acid and 2,5-difluorobenzaldehyde are reacting in the presence a base catalyser. Piperidine is a commonly used base catalyst in such reactions.Piperidine is commonly used as a base catalyst in these reactions. The reaction is usually carried out in a suitable solvent.The reaction is carried out in a solvent. Pyridine is a good choice as a solvent because it can dissolve both the reactants and the catalyst, and also has a relatively high boiling point, which helps to drive the reaction to completion.Pyridine can be used as a solvent, because it dissolves both the reactants, and the catalyst. It also has a high boiling point that helps drive the reaction through to completion.
The reaction proceeds as follows: the base catalyst deprotonates malonic acid, generating a carbanion.The reaction proceeds in the following way: the base catalyst deprotonates malonic acids, generating carbanion. This carbanion then attacks the carbonyl carbon of 2,5 - difluorobenzaldehyde. Subsequently, a series of proton - transfer and elimination reactions occur.A series of proton-transfer and elimination reactions follow. The elimination of a molecule of carbon dioxide from the intermediate formed leads to the formation of (2E)-3-(2,5 - Difluorophenyl)acrylic acid.
The reaction conditions need to be carefully controlled.The reaction conditions must be carefully controlled. The temperature is typically maintained in the range of 80 - 120 degC.Temperatures are typically kept between 80 and 120 degC. Higher temperatures may lead to side reactions, while lower temperatures may result in a slow reaction rate.Lower temperatures can cause a slower reaction rate, while higher temperatures may cause side reactions. The reaction time can range from several hours to overnight depending on the reaction scale and the efficiency of the reaction system.The reaction time may range from several hours up to overnight, depending on the scale of the reaction and the efficiency level of the system.

3. Product isolation and purification3.
After the reaction is complete, the reaction mixture is cooled.After the reaction has been completed, the reaction mixture must be cooled. The product can be isolated by acidifying the reaction mixture.Acidifying the reaction mixture allows for the isolation of the product. This converts any basic salts formed during the reaction back to the carboxylic acid form.This converts any salts that are formed during the reaction to carboxylic acids. The crude product is then often extracted with an organic solvent such as ethyl acetate.The crude product can then be extracted using an organic solvent, such as ethyl-acetate. The organic layer is separated, dried over anhydrous sodium sulfate to remove any remaining water, and then the solvent is evaporated under reduced pressure.The organic layer is separated and dried over anhydrous Sodium Sulfate in order to remove any remaining moisture.
The resulting crude product can be further purified by recrystallization.The crude product obtained can be purified further by recrystallization. A suitable solvent system for recrystallization is chosen, for example, a mixture of ethanol and water.Recrystallization can be carried out using a suitable solvent system, such as ethanol and water. The recrystallization process helps to remove any remaining impurities, resulting in pure (2E)-3-(2,5 - Difluorophenyl)acrylic acid.

What are the safety hazards of (2E)-3-(2,5-Difluorophenyl)acrylic acid, trans-3-(2,5-Difluorophenyl)prop-2-enoic acid?

(2E)-3-(2,5 - Difluorophenyl)acrylic acid, also known as trans - 3-(2,5 - Difluorophenyl)prop - 2 - enoic acid, may pose several safety hazards.
Firstly, in terms of health hazards, it may cause skin irritation.In terms of health hazards, the product can cause skin irritation. Direct contact with the skin can lead to redness, itching, and possible allergic reactions in some individuals.Direct contact with the body can cause redness, itchiness, and allergic reactions in some people. This is because the chemical structure of the compound may interact with the skin's protective layer and trigger an inflammatory response.The chemical structure of the compound can interact with the skin's outer layer to trigger an inflammatory reaction.

Secondly, it can be an eye irritant.Second, it can irritate the eyes. If it gets into the eyes, it can cause severe discomfort, pain, and may even damage the eye tissues.If it gets in the eyes, it may cause severe discomfort, pain and even damage to the eye tissues. The presence of fluorine atoms in the molecule might contribute to its reactivity and potential harm to the sensitive tissues of the eyes.The presence of fluorine in the molecule may contribute to its reactivity, and the potential harm it could cause to sensitive tissues of the eye.

Inhalation of dust or vapors containing this acid can be harmful to the respiratory system.Inhaling dust or vapors that contain this acid can cause respiratory problems. It may cause coughing, shortness of breath, and irritation of the airways.It can cause coughing, shortness breath, and irritation to the airways. Prolonged or repeated inhalation could potentially lead to more serious respiratory problems such as bronchitis or reduced lung function.Inhaling the substance repeatedly or for a long time could lead to respiratory problems like bronchitis and reduced lung function.

Regarding environmental hazards, when (2E)-3-(2,5 - Difluorophenyl)acrylic acid is released into the environment, it may have an impact on aquatic life. Fluorinated organic compounds can be persistent in water bodies and may accumulate in organisms over time.Fluorinated organic substances can accumulate in organisms and persist in water bodies. This can disrupt the ecological balance of aquatic ecosystems, affecting the growth, reproduction, and survival of various aquatic species.This can disrupt the balance of aquatic ecosystems by affecting the growth and reproduction of aquatic species.

In addition, if it enters the soil, it might potentially affect soil microorganisms and plant growth.It could also affect soil microorganisms or plant growth if it gets into the soil. The fluorine - containing structure may make it less biodegradable compared to some non - fluorinated organic acids, leading to long - term presence in the soil and possible negative impacts on soil fertility and plant health.Its fluorine-containing structure could make it less biodegradable than some non-fluorinated organic acid, resulting in a long-term presence in the soil with possible negative impacts on plant health and soil fertility.

Overall, proper handling, storage, and disposal of (2E)-3-(2,5 - Difluorophenyl)acrylic acid are crucial to minimize these safety hazards to human health and the environment.