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Product Name | 2-Acetamidoacrylic acid methyl ester |
Cas Number | 56687-79-9 |
Formula | C6H9NO3 |
Molar Mass | 143.14 g/mol |
Melting Point | N/A |
Boiling Point | N/A |
Density | N/A |
Solubility In Water | N/A |
Vapor Pressure | N/A |
Refractive Index | N/A |
Flash Point | N/A |
Pka | N/A |
Appearance | N/A |
Odor | N/A |
Stability | N/A |
What are the main applications of 2-Acetamidoacrylic acid methyl ester?
2 - Acetamidoacrylic acid methyl ester has several main applications:The methyl ester of acetamidoacrylic acids has many applications.
In the field of organic synthesis, it serves as a crucial intermediate.It is a key intermediate in organic synthesis. Its unique structure allows for the introduction of the acetamido and acrylate moieties into various organic molecules.Its unique structure allows the introduction of acetamido or acrylate moieties in various organic molecules. Chemists can use it to build more complex organic compounds.Chemists use it to create more complex organic compounds. For example, through reactions like Michael addition, it can react with nucleophiles to form new carbon - carbon or carbon - heteroatom bonds.It can, for example, react with nucleophiles through Michael addition to form new heteroatom or carbon-carbon bonds. This enables the synthesis of molecules with diverse functional groups, which are often required in the development of pharmaceuticals, agrochemicals, and fine chemicals.This allows the synthesis of molecules that have diverse functional groups. These are often needed in the development and production of pharmaceuticals, fine chemicals, and agrochemicals.
Regarding pharmaceutical applications, 2 - Acetamidoacrylic acid methyl ester can be a starting material for the synthesis of bioactive compounds.In pharmaceutical applications, 2- Acetamidoacrylic Acid methyl Ester can be used as a starting material to synthesize bioactive compounds. It may contribute to the construction of drug molecules with specific biological activities.It can be used to create drug molecules with specific biological properties. Some derivatives synthesized from it might have antibacterial, antifungal, or anti - inflammatory properties.Some derivatives synthesized using it may have antibacterial or antifungal properties. By modifying its structure through subsequent chemical reactions, researchers can optimize the biological activity, solubility, and pharmacokinetic properties of potential drug candidates.Researchers can modify its structure by modifying subsequent chemical reactions to optimize biological activity, solubility and pharmacokinetics of potential drug candidates.
In the production of polymers, this compound can play a role in copolymerization reactions.This compound can be used in the copolymerization reaction to produce polymers. When copolymerized with other monomers, it can impart unique properties to the resulting polymers.Copolymerized monomers can give unique properties to polymers. For instance, the acetamido group can enhance the hydrophilicity of the polymer, while the acrylate part allows for cross - linking and polymerization.The acetamido groups can increase the hydrophilicity, while the acrylate group allows for polymerization and cross-linking. These copolymers may find applications in areas such as coatings, adhesives, and hydrogels.These copolymers can be used in coatings, hydrogels, and adhesives. In coatings, they can improve the adhesion to substrates and provide better protection.In coatings, these copolymers can improve adhesion and provide better protection. In hydrogels, the hydrophilic nature can help in water absorption and retention, which is useful in applications like wound dressings and drug delivery systems.Hydrogels can be useful for applications such as wound dressings or drug delivery because of their hydrophilic nature.
It also has potential applications in the field of material science.It has potential applications also in the field material science. For example, in the preparation of advanced materials with tailored properties.It can be used to prepare advanced materials with tailored characteristics. By incorporating 2 - Acetamidoacrylic acid methyl ester into materials, properties such as mechanical strength, chemical resistance, and surface functionality can be adjusted.By incorporating 2-Acetamidoacrylic Acid methyl Ester into materials, properties like mechanical strength, chemical resistance and surface functionality can all be adjusted. This can lead to the development of new materials for use in electronics, automotive, and aerospace industries, where materials with specific and optimized properties are highly demanded.This can lead to new materials being developed for the electronics, automotive and aerospace industries where materials with specific properties and optimized properties are highly desired. Overall, 2 - Acetamidoacrylic acid methyl ester is a versatile compound with a wide range of applications across different scientific and industrial sectors.2 - Acetamidoacrylic Acid methyl Ester is a versatile chemical compound that has many applications in different scientific and industrial fields.
What are the physical and chemical properties of 2-Acetamidoacrylic acid methyl ester?
2 - Acetamidoacrylic acid methyl ester is an organic compound with the following physical and chemical properties:Acetamidoacrylic Acid Methyl Ester is a compound that has the following physical and chemistry properties:
Physical properties:Physical Properties
Appearance: It is often in the form of a solid or a viscous liquid, depending on the purity and environmental conditions.Appearance: It can be a solid, or viscous liquid depending on the purity of the substance and the environmental conditions. The color can range from colorless to slightly yellowish, indicating a relatively pure state or the presence of minor impurities respectively.The color can vary from colorless to slightly golden, indicating either a relatively pure condition or the presence minor impurities.
Melting and boiling points: The melting point is an important characteristic that helps in identifying and purifying the compound.Melting and boiling point: The melting and boiling point are important characteristics that help identify and purify the compound. Precise values can vary based on factors like crystal structure and purity.The exact values can vary depending on factors such as crystal structure and purity. Its boiling point is also significant as it gives an idea about its volatility.The boiling point of a substance is also important because it gives a good idea of its volatility. These values are determined through standard laboratory techniques such as differential scanning calorimetry for melting point and distillation - based methods for boiling point.These values are determined using standard laboratory techniques, such as differential scanning calorimetry to determine melting point and distillation-based methods to determine boiling point.
Solubility: 2 - Acetamidoacrylic acid methyl ester has specific solubility characteristics.Solubility: Acetamidoacrylic Acid methyl ester possesses specific solubility properties. It shows some solubility in polar organic solvents such as ethanol and methanol.It is soluble in polar organic solvents like ethanol and methanol. This solubility is due to the presence of polar functional groups in the molecule, like the amide and ester groups, which can form hydrogen bonds with the solvent molecules.This is due to polar functional groups like amide and ester groups that can form hydrogen bonds with solvent molecules. However, it has limited solubility in non - polar solvents like hexane, as the non - polar part of the molecule is not sufficient to interact favorably with non - polar solvent molecules.It has limited solubility with non-polar solvents such as hexane because the non-polar part of molecule is insufficient to interact favorably.
Chemical properties:Chemical properties
Reactivity of the ester group: The methyl ester part of 2 - Acetamidoacrylic acid methyl ester is reactive.Reactivity of the ester groups: The methyl ester part of 2 – Acetamidoacrylic Acid methyl ester (acetamidoacrylic acid is methyl ester) is reactive. It can undergo hydrolysis reactions in the presence of water, either under acidic or basic conditions.It can undergo hydrolysis reactions when water is present, either in acidic or basic conditions. In acidic hydrolysis, the ester bond is cleaved, producing 2 - acetamidoacrylic acid and methanol.In acidic hydrolysis the ester bond is broken, resulting in 2 - acetamidoacrylic acids and methanol. Under basic hydrolysis (saponification), the reaction yields the carboxylate salt of 2 - acetamidoacrylic acid and methanol.Under basic hydrolysis, the reaction produces the carboxylate of 2 -acetamidoacrylic and methanol.
Reactivity of the amide group: The amide group also contributes to the chemical reactivity of the compound.Reactivity of amide group: the amide group contributes to the chemical reaction of the compound. It can participate in reactions such as acylation or amidation under appropriate reaction conditions.It can be involved in reactions like acylation and amidation when the conditions are right. For example, it can react with acylating agents to form more complex amide derivatives.It can, for example, react with acylating compounds to form more complex amides.
Double bond reactivity: The compound contains a carbon - carbon double bond, which makes it susceptible to addition reactions.Double bond reactivity. The compound has a double carbon-carbon bond that makes it susceptible to reaction additions. For instance, it can react with halogens (such as bromine) in an addition reaction, where the double bond is broken, and halogen atoms are added to the carbon atoms of the double bond.In an addition reaction with halogens, such as bromine, the double bonds are broken and halogens atoms added to the carbons of the double bonds. This double bond can also be used in polymerization reactions to form polymers with unique properties, depending on the reaction conditions and the other monomers involved.This double bond is also used in polymerization to create polymers with unique properties depending on the reaction conditions, and the other monomers that are involved.
How is 2-Acetamidoacrylic acid methyl ester synthesized?
2 - Acetamidoacrylic acid methyl ester can be synthesized through the following general approach.The following general method can be used to synthesize 2 - Acetamidoacrylic Acid methyl ester.
One common method starts with the reaction of malonic acid derivatives.A common method begins with the reaction between malonic acid derivatives. Malonic acid or its esters can be used as starting materials.As a starting material, malonic acid or its ester can be used. First, the malonic acid derivative is reacted with acetic anhydride or acetyl chloride in the presence of a suitable base.The malonic acid derivative must first be reacted with either acetic chloride or anhydride in the presence a suitable base. The base helps to facilitate the acylation reaction.The base facilitates the acylation. For example, if we use sodium acetate as the base, it can abstract a proton from the malonic acid derivative, making it more nucleophilic towards the acetylating agent.If we use sodium as a base, it can remove a proton, making the malonic derivative more nucleophilic to the acetylating agents. This reaction leads to the formation of an intermediate with an acetylated carbonyl group adjacent to the ester functionality.This reaction results in the formation of a carbonyl group with an acetylated function adjacent to the ester functionality.
Next, this intermediate undergoes a decarboxylation reaction.This intermediate is then subjected to a decarboxylation. Heating the intermediate is often sufficient to drive off carbon dioxide, resulting in the formation of an unsaturated compound.The intermediate can be heated to remove carbon dioxide and form an unsaturated compound. This unsaturated compound has the basic structure of 2 - Acetamidoacrylic acid derivative.This unsaturated compound is a derivative of 2 - Acetamidoacrylic Acid.
To obtain the methyl ester form, an esterification reaction is carried out.Esterification is used to obtain the methyl esters. If the intermediate is in the form of an acid, it can be reacted with methanol in the presence of an acid catalyst, such as sulfuric acid or p - toluenesulfonic acid.In the presence of an acids catalyst such as sulfuric or p-toluenesulfonic acids, the intermediate can be reacted to methanol. The acid catalyst protonates the carbonyl oxygen of the carboxylic acid, enhancing its electrophilicity.The acid catalyst protonates carbonyl oxygen in the carboxylic acids, increasing their electrophilicity. Methanol then attacks the carbonyl carbon, followed by a series of proton transfers and elimination steps to form the methyl ester of 2 - Acetamidoacrylic acid.Methanol attacks the carbonyl atom, followed by a number of proton transfer and elimination steps.
Another possible synthetic route could involve starting from glycine derivatives.Another possible route would be to start with glycine derivatives. Glycine can be first acetylated to form N - acetylglycine.Glycine is first acetylated into N-acetylglycine. Then, through a series of reactions to introduce the double bond and the methyl ester group.The double bond is introduced through a series reactions. For instance, by reacting N - acetylglycine with appropriate reagents that can promote the formation of a double bond adjacent to the amide group and simultaneously introduce the methyl ester functionality.By reacting N-acetylglycine to appropriate reagents, you can promote the formation a double bond next to the amide groups and introduce the methyl ester functionality. This might involve reactions with reagents like phosphorus oxychloride in combination with methanol in a carefully controlled reaction sequence.This could involve reactions using reagents such as phosphorus chloride in combination with the methanol, in a carefully-controlled reaction sequence. The phosphorus oxychloride can activate the carboxylic acid group of N - acetylglycine, enabling subsequent reactions to form the unsaturated methyl ester product.The phosphorus oxide can activate the carboxylic group of N-acetylglycine to enable subsequent reactions that lead to the formation of the unsaturated methyl ester product.
In all these synthetic methods, proper reaction conditions such as temperature, reaction time, and stoichiometry of reactants need to be carefully optimized to ensure high yields and purity of the 2 - Acetamidoacrylic acid methyl ester product.All of these methods require that the reaction conditions, such as temperature, time and stoichiometry, are optimized to achieve high yields and purity. Also, appropriate purification techniques like column chromatography or recrystallization may be required to isolate the final product in its pure form.Purification techniques such as column chromatography and recrystallization are also required to isolate the pure form of the final product.
What are the safety precautions when handling 2-Acetamidoacrylic acid methyl ester?
2 - Acetamidoacrylic acid methyl ester is a chemical compound that requires certain safety precautions during handling.Acetamidoacrylic Acid methyl Ester is a chemical that requires special precautions when handling.
First, personal protective equipment is essential.Personal protective equipment is a must. Wear appropriate protective clothing, such as long - sleeved lab coats or coveralls, to prevent skin contact.Wear protective clothing such as long-sleeved lab jackets or coveralls to avoid skin contact. Chemical - resistant gloves made of materials like nitrile are necessary.Chemical-resistant gloves made from materials such as nitrile will be required. This helps to avoid direct contact of the chemical with the skin, as skin exposure can potentially lead to irritation, allergic reactions, or absorption into the body.It is important to avoid direct skin contact with the chemical. This can cause irritation, allergic reactions or absorption of the chemical into the body.
Eye protection is also crucial.Eye protection is equally important. Safety goggles or a face shield should be worn at all times when handling 2 - Acetamidoacrylic acid methyl ester.Wear safety goggles or face shields at all times while handling 2- Acetamidoacrylic Acid methyl Ester. In case of accidental splashing, these can prevent the chemical from getting into the eyes, which could cause serious eye damage, including burns and vision impairment.These can be used to prevent chemical splashes from entering the eyes. This could lead to serious eye damage including burns and vision loss.
Work in a well - ventilated area.Work in an area that is well-ventilated. Adequate ventilation helps to prevent the build - up of vapors.Adequate ventilation prevents the build-up of vapors. If the work is being carried out in a laboratory, use a fume hood.Use a fume-hood if you are working in a lab. The fume hood can effectively remove any volatile chemicals or vapors generated during handling, reducing the risk of inhalation.The fume hood will remove any volatile chemicals and vapors that are generated during handling. This will reduce the risk of inhalation. Inhalation of the vapors may cause respiratory problems, such as coughing, shortness of breath, and irritation of the respiratory tract.Inhalation of vapors can cause respiratory problems such as coughing and shortness of breathe.
When handling the compound, be careful to avoid spills.Avoid spills when handling the compound. In the event of a spill, immediately take appropriate cleanup measures.If a spill occurs, take immediate action to clean it up. First, isolate the area to prevent others from accidentally coming into contact with the spilled chemical.Isolate the area first to prevent others from accidentally contacting the chemical. Use absorbent materials, such as spill pillows or absorbent pads, to soak up the liquid.To absorb the liquid, use absorbent materials such as absorbent pads or spill pillows. Dispose of the contaminated absorbents according to local regulations for chemical waste.Dispose the contaminated absorbents in accordance with local regulations on chemical waste.
Store 2 - Acetamidoacrylic acid methyl ester properly. Keep it in a cool, dry place away from heat sources, flames, and oxidizing agents.Store it in a dry, cool place away from heat, flames and oxidizing agents. It should be stored in a tightly - sealed container to prevent evaporation and leakage.Store it in a tightly-sealed container to prevent evaporation. Clearly label the storage container with the name of the chemical, its hazard information, and any specific handling instructions.Label the container clearly with the name of chemical, the hazard information and any specific instructions.
Finally, be familiar with the first - aid procedures in case of an accident.Be familiar with first-aid procedures in the event of an accident. In case of skin contact, immediately wash the affected area with plenty of water for at least 15 minutes and seek medical attention if irritation persists.If skin contact occurs, wash the area thoroughly with water for at least fifteen minutes. Seek medical attention if irritation continues. If the chemical gets into the eyes, flush the eyes with copious amounts of water for at least 15 minutes and then seek immediate medical help.If the chemical gets in the eyes, flush them with plenty of water for 15 minutes. Then seek immediate medical attention. In case of inhalation, move the affected person to fresh air and seek medical assistance if breathing difficulties occur.If the chemical is inhaled, move to fresh air if possible and seek medical attention if breathing problems occur.
What are the storage requirements for 2-Acetamidoacrylic acid methyl ester?
2 - Acetamidoacrylic acid methyl ester is a chemical compound that requires proper storage to maintain its quality and safety.Acetamidoacrylic Acid methyl Ester is a chemical that requires proper storage in order to maintain its safety and quality. Here are the main storage requirements.Here are the main requirements for storage.
Firstly, storage location is crucial.First, the location of storage is important. It should be stored in a cool, well - ventilated area.It should be kept in a well-ventilated, cool area. High temperatures can accelerate chemical reactions, potentially leading to decomposition or changes in the properties of 2 - acetamidoacrylic acid methyl ester.High temperatures can accelerate chemical reaction, which could lead to 2 - acetamidoacrylic acids methyl ester decomposition or changing properties. A temperature range between 2 - 8degC is often ideal for many chemicals of this nature, as it helps to slow down any thermally - induced degradation processes.Temperatures between 2 and 8degC are ideal for many of these chemicals, as they help to slow down thermally-induced degradation processes. The well - ventilated aspect is important to prevent the build - up of potentially harmful vapors.It is important that the space be well-ventilated to prevent the accumulation of potentially harmful vapors. In a poorly ventilated space, if the compound were to release any volatile components, the concentration of these vapors could increase to dangerous levels, posing risks such as explosion or inhalation hazards.If the compound releases volatile components in a poorly ventilated area, the concentration of these gases could reach dangerous levels and pose risks such as explosions or inhalation hazards.
Secondly, the storage container is of great significance.The storage container is also very important. It should be made of a material that is compatible with 2 - acetamidoacrylic acid methyl ester.It should be made from a material compatible with 2-acetamidoacrylic-methyl ester. For example, glass containers are often a good choice as they are relatively inert and do not react easily with many chemicals.Glass containers are a popular choice because they are relatively inert, and don't react with many chemicals. However, if metal containers are considered, it must be ensured that the metal does not corrode or initiate chemical reactions with the compound.Metal containers must not corrode, or cause chemical reactions, with the compound. The container should also be tightly sealed.The container must also be tightly closed. An open or leaky container can allow moisture to enter, which might cause hydrolysis reactions in 2 - acetamidoacrylic acid methyl ester.Moisture can enter an open or leaking container, causing hydrolysis reactions to occur in 2 - Acetamidoacrylic Acid methyl Ester. Moisture can also lead to the growth of microorganisms in some cases, further degrading the compound.Moisture may also cause the growth of microorganisms, which can further degrade the compound.
Thirdly, it is necessary to store 2 - acetamidoacrylic acid methyl ester away from sources of ignition, heat, and oxidizing agents.Thirdly, 2 - Acetamidoacrylic Acid methyl Ester should be stored away from sources such as heat, ignition, and oxidizing agents. As an organic compound, it may be flammable under certain conditions.It is flammable because it is an organic compound. Ignition sources like open flames, sparks from electrical equipment, or hot surfaces can potentially ignite it.It can be ignited by sources of ignition such as open flames, sparks generated by electrical equipment or hot surfaces. Oxidizing agents can react violently with the compound, leading to uncontrolled chemical reactions that could result in fires, explosions, or the formation of harmful by - products.Oxidizing agents may react violently with this compound, causing uncontrolled chemical reactions. These reactions could lead to fires, explosions or the formation harmful by-products.
Finally, proper labeling of the storage container is essential.Labeling the container is also important. The label should clearly indicate the name of the compound, its chemical formula, any relevant hazard warnings such as flammability or toxicity, and the date of storage.The label should clearly state the name of the compound and its chemical formula. It should also include any relevant warnings, such as flammability, toxicity, or other hazards. This information is not only useful for ensuring correct handling during storage but also in case of emergencies.This information is useful not only for ensuring proper handling during storage, but also in the event of an emergency. If there is a spill or other incident, responders can quickly identify the substance and take appropriate safety measures based on the information provided on the label.The information on the label can help responders quickly identify the substance in the event of a spillage or other incident. They can then take the appropriate safety measures.