| product_name | 2-(Trifluoromethyl)acrylic acid |
| CAS_number | 328-45-0 |
| formula | C5H3F3O2 |
| molar_mass | 166.07 g/mol |
| physical_state | solid |
| color | white |
| odor | odorless |
| melting_point | 115-117°C |
| boiling_point | 268-270°C |
| density | 1.547 g/cm3 |
| solubility | slightly soluble in water |
| flash_point | 121°C |
What is 2-(Trifluoromethyl)acrylic acid?
2-(Trifluoromethyl)acrylic acid, also known as CF3COOH, is a strong organic acid commonly used in various applications such as pharmaceuticals, agrochemicals, and materials science. It is a colorless liquid with a pungent odor and is highly soluble in water.
What are the main uses of 2-(Trifluoromethyl)acrylic acid?
2-(Trifluoromethyl)acrylic acid is primarily used as a key intermediate in the synthesis of pharmaceutical compounds, including antiviral drugs and antifungal agents. It is also utilized in the manufacturing of herbicides, insecticides, and specialty chemicals due to its excellent reactivity and versatile properties.
What are the benefits of using 2-(Trifluoromethyl)acrylic acid in pharmaceutical applications?
When used in pharmaceutical applications, 2-(Trifluoromethyl)acrylic acid offers several advantages. It can effectively enhance the bioactivity and potency of drug molecules, improve their stability and solubility, as well as enable the introduction of fluorine atoms for improved pharmacokinetic properties.
How is 2-(Trifluoromethyl)acrylic acid synthesized?
2-(Trifluoromethyl)acrylic acid is typically synthesized through the reaction of trifluoroacetic anhydride with formaldehyde in the presence of a catalyst. The resulting intermediate is then oxidized to yield the desired product, which can be further purified and isolated for use in various applications.
What are the safety considerations when handling 2-(Trifluoromethyl)acrylic acid?
Due to its strong acidic nature, 2-(Trifluoromethyl)acrylic acid should be handled with care and precaution. It is corrosive to skin and eyes and can cause irritation upon contact. Proper personal protective equipment, such as gloves, goggles, and lab coats, should be worn when working with this compound.
What are the storage requirements for 2-(Trifluoromethyl)acrylic acid?
2-(Trifluoromethyl)acrylic acid should be stored in a cool, dry, and well-ventilated area away from sources of heat or ignition. It should be kept in a tightly sealed container to prevent moisture absorption and contamination. Additionally, it should be stored separately from incompatible materials to avoid potential reactions.
Can 2-(Trifluoromethyl)acrylic acid be customized for specific applications?
Yes, 2-(Trifluoromethyl)acrylic acid can be customized and tailored to meet specific requirements for different applications. By adjusting reaction conditions, modifying chemical structures, or incorporating additional functional groups, the properties and performance of this compound can be optimized for desired outcomes.
What quality control measures are in place for 2-(Trifluoromethyl)acrylic acid?
To ensure the highest quality and purity of 2-(Trifluoromethyl)acrylic acid, rigorous quality control measures are implemented throughout the synthesis, purification, and testing processes. Analytical techniques such as NMR spectroscopy, GC-MS analysis, and HPLC are used to verify the identity, composition, and purity of the product.
Are there any ongoing research or development initiatives involving 2-(Trifluoromethyl)acrylic acid?
Yes, ongoing research and development initiatives are exploring new applications, synthetic methodologies, and innovative uses for 2-(Trifluoromethyl)acrylic acid. These efforts aim to further expand the utility and versatility of this compound in various industries, including pharmaceuticals, materials science, and chemical synthesis.