What is the chemical structure of 3-(6-amino-pyridin-3-yl) acrylic acid ethyl ester?

3-(6 - amino - pyridin - 3 - yl) acrylic acid ethyl ester is an organic compound with a specific chemical structure.The 3-(6- amino-pyridin- 3- yl-) acrylic acid ethyl ester is an organic compound that has a specific chemical composition.
Let's break down its structure description.Let's describe its structure. The core part contains a pyridine ring.The core part contains the pyridine ring. A pyridine ring is a six - membered aromatic heterocyclic ring where one of the carbon atoms is replaced by a nitrogen atom.A pyridine is a six-membered aromatic heterocyclic chain where one carbon atom is replaced by a Nitrogen atom. In this case, the pyridine ring has specific substituents.In this case, pyridine rings have specific substituents. At the 6 - position of the pyridine ring, there is an amino group (-NH2).The amino group (-NH2) is located at the 6 -position of the pyridine rings. The amino group consists of a nitrogen atom bonded to two hydrogen atoms.The amino group is made up of a nitrogen atom and two hydrogen atoms.

Connected to the 3 - position of the pyridine ring is an acrylic acid ethyl ester moiety.The acrylic acid ethyl ester moiety is connected to the 3 – position of the pyridine. The acrylic acid part has a structure of a vinyl group (-CH=CH2) attached to a carboxylic acid group (-COOH).The acrylic acid part is composed of a vinyl group attached to a carboxylic group (-COOH). However, in this compound, the carboxylic acid group of the acrylic acid has formed an ester with an ethyl group (-C2H5).In this compound, however, the carboxylic group of the acrylic has formed an ester with an ethyl (-C2H5) group. The ester linkage is formed by the reaction of the carboxylic acid's -OH group with the -OH group of ethanol, resulting in the formation of -COO - C2H5.The ester linkage occurs when the carboxylic acid -OH reacts with the ethanol -OH, resulting in -COO-C2H5.

Overall, the structure can be thought of as the pyridine ring being the central unit, with the amino group on one side and the modified acrylic acid ethyl ester on the other side.The pyridine ring is the central unit of the structure, with the amino groups on one side, and the modified acrylic acid ester on the opposite side. This combination of the aromatic pyridine ring, the amino functional group, and the ester - containing acrylic acid derivative gives the compound unique chemical and physical properties.The combination of the aromatic, pyridine ring with the amino functional group and the ester-containing acrylic acid derivative give the compound unique physical and chemical properties. These properties can potentially make it useful in various fields such as organic synthesis, drug development, or as a building block for more complex molecules due to the reactivity of the amino group, the unsaturation in the acrylic part, and the stability provided by the ester and the aromatic ring.These properties could make it useful for a variety of fields, such as organic synthesis or drug development.

What are the applications of 3-(6-amino-pyridin-3-yl) acrylic acid ethyl ester?

3-(6 - amino - pyridin - 3 - yl) acrylic acid ethyl ester is a compound with potential applications in multiple fields.The 3-(6- amino-pyridin- 3- yl-) acrylic acid ethyl ester is a compound that has potential applications in many fields.
In the pharmaceutical industry, it can serve as an important intermediate for drug synthesis.It can be used as a drug intermediate in the pharmaceutical industry. The pyridine ring and the acrylate ester moiety in its structure endow it with unique chemical reactivity.Its unique chemical reactivity is due to the pyridine ring in its structure and the acrylate ester moiety. Compounds containing pyridine rings often show biological activities such as antibacterial, antifungal, and anti - inflammatory properties.Compounds with pyridine rings are often biologically active, exhibiting antibacterial, antifungal and anti-inflammatory properties. By modifying the 3-(6 - amino - pyridin - 3 - yl) acrylic acid ethyl ester through various chemical reactions, new drug candidates can be developed.Through various chemical reactions it is possible to develop new drug candidates by modifying the 3-(6- amino-pyridin- 3 -yl)acryl acid ethyl ester. For example, the amino group can be further functionalized to interact with specific biological targets within the body, potentially leading to the creation of drugs for treating diseases like infectious diseases or chronic inflammatory conditions.The amino group, for example, can be further functionalized in order to interact with biological targets within the human body. This could lead to the creation of drugs to treat diseases such as infectious diseases or chronic inflammation conditions.

In the field of materials science, this compound can be used in the synthesis of specialty polymers.This compound can be used to synthesize specialty polymers in the field of materials sciences. The double bond in the acrylic acid ethyl ester part can participate in polymerization reactions.The double bond of the acrylic acid ethyl ester part can be involved in polymerization reactions. Incorporating 3-(6 - amino - pyridin - 3 - yl) acrylic acid ethyl ester into polymer backbones can introduce unique properties. The pyridine - amino moiety can enhance the polymer's ability to bind to certain substances, making it useful in applications such as ion - exchange resins.The pyridine-amino moiety can enhance a polymer's ability of binding to certain substances. This makes it useful for applications such as ion-exchange resins. These resins can selectively adsorb and release ions, which is valuable in water treatment processes to remove heavy metals or in chemical separation techniques to purify mixtures.These resins are able to selectively adsorb ions and release them, which is useful in water treatment processes for removing heavy metals or chemical separation techniques for purifying mixtures.

It may also find applications in the area of organic synthesis research.It could also be used in research on organic synthesis. Due to its complex structure with multiple reactive sites, it can be used as a model compound to study reaction mechanisms.It can be used to study reaction mechanisms due to its complex structure and multiple reactive sites. Chemists can explore how different reagents react with the amino group, the pyridine ring, and the acrylate ester group.Chemists are able to explore the reactions of different reagents with the amino group, pyridine ring and acrylate ester groups. This knowledge can then be applied more broadly in organic synthesis to develop new synthetic routes for other complex organic molecules.This knowledge can be used to develop new synthetic routes of other complex organic molecules. Understanding the reactivity of 3-(6 - amino - pyridin - 3 - yl) acrylic acid ethyl ester can lead to more efficient and selective chemical reactions, which is crucial for the large - scale production of various organic compounds in the chemical industry.Understanding the reactivity and selectivity of 3-(6- amino pyridin- 3 yl)acryl acid ethyl ester can lead to more efficient chemical reactions. This is important for the large-scale production of organic compounds.

What are the properties of 3-(6-amino-pyridin-3-yl) acrylic acid ethyl ester?

3-(6 - amino - pyridin - 3 - yl) acrylic acid ethyl ester has several properties.The 3-(6- amino-pyridin- 3- yl)acrylic acid ethyl ester has many properties.
1. Chemical Structure - Related PropertiesChemical Structure - Related Property
The compound contains a pyridine ring with an amino group at the 6 - position and an acrylic acid ethyl ester moiety attached to the 3 - position of the pyridine ring.The compound has a pyridine moiety with an amino group in the 6 -position and an acrylic acid-ethyl ester moiety attached at the 3 – position of the pyridine. The pyridine ring imparts aromaticity to the molecule.The pyridine ring gives the molecule its aromaticity. Aromatic compounds often have relatively high stability due to the delocalization of p - electrons within the ring.Aromatic compounds are often stable due to the delocalization p-electrons within the ring. The amino group (-NH2) is a basic functional group.The amino group (NH2) is the basic functional group. It can participate in hydrogen - bonding as a hydrogen - bond donor.It can act as a hydrogen-bond donor. This hydrogen - bonding ability can influence the compound's solubility in polar solvents and its intermolecular interactions.This hydrogen-bonding ability can affect the compound's intermolecular interaction and its solubility in polar solvants. The acrylic acid ethyl ester part contains a carbon - carbon double bond and an ester group.The acrylic acid ethyl ester part contains a double carbon-carbon bond and an ester. The carbon - carbon double bond is reactive and can undergo addition reactions, such as electrophilic addition with reagents like bromine or hydrogen halides.The carbon-carbon double bond is reactive, and can undergo addition reaction such as electrophilic addtion with reagents such as bromine or hydrogen chlorides. The ester group (-COOCH2CH3) is relatively stable but can be hydrolyzed under acidic or basic conditions.The ester group (COOCH2CH3), although relatively stable, can be hydrolyzed in acidic or basic conditions.

2. Physical PropertiesPhysical Properties
In terms of solubility, the presence of the polar amino group and the relatively polar ester group means that the compound has some solubility in polar solvents such as alcohols and water - miscible organic solvents like dimethyl sulfoxide (DMSO).The presence of a polar amino group, and a relatively polar ester group, means that the compound is soluble in polar solvents. These include alcohols and water – miscible organics like dimethyl sulfoxide. However, the hydrophobic nature of the pyridine ring and the ethyl part of the ester group may limit its solubility in pure water.The hydrophobic nature the pyridine group and the ethyl portion of the ester may limit the solubility of this compound in pure water. The melting and boiling points of this compound are influenced by its intermolecular forces.Intermolecular forces influence the melting and boiling points. The hydrogen - bonding from the amino group can increase the intermolecular attractions, resulting in relatively higher melting and boiling points compared to non - hydrogen - bonding analogs.The hydrogen-bonding from the amino-group can increase intermolecular attraction, resulting in higher melting and boiling temperatures compared to analogs without hydrogen-bonding. But these values would also be affected by the overall molecular size and shape.These values are also affected by the size and shape of the molecule.

3. Spectroscopic PropertiesSpectroscopic Properties
In the infrared (IR) spectrum, characteristic peaks can be observed.In the infrared spectrum (IR), characteristic peaks are visible. The amino group will show a broad absorption in the region around 3300 - 3500 cm-1 corresponding to the N - H stretching vibrations.The amino group will exhibit a broad absorption around 3300-3500 cm-1, which corresponds to the N-H stretching vibrations. The carbonyl group of the ester will have a strong absorption around 1700 - 1750 cm-1 for the C = O stretching vibration.The carbonyl group in the ester has a strong vibrational absorption of 1700-1750 cm-1. The carbon - carbon double bond in the acrylic acid part will show an absorption around 1600 - 1650 cm-1 for the C = C stretching.The C = C stretching will cause the carbon-carbon double bond in the part of acrylic acid to show an absorption between 1600 - 1650 cm-1. In the nuclear magnetic resonance (NMR) spectra, the protons on the pyridine ring, the amino group, the ethyl group of the ester, and the protons on the acrylic acid part will give distinct signals, allowing for the determination of the compound's structure and purity.The protons of the pyridine ring will show distinct signals in the nuclear magnetic resonance (NMR). This allows the compound's purity and structure to be determined.

4. Reactivity
As mentioned, the carbon - carbon double bond is prone to addition reactions.As previously mentioned, the double carbon-carbon bond is susceptible to addition reactions. For example, it can be used in Diels - Alder reactions if appropriate reaction conditions are met, reacting with a dienophile to form a cyclic product.If the reaction conditions are right, it can be used to form a cyclic compound in Diels-Alder reactions. The amino group can be acylated or alkylated under suitable reaction conditions.Under suitable conditions, the amino group can be alkylated or acylated. The ester group can be saponified in the presence of a base to form the corresponding carboxylic acid and ethanol.The ester group is saponified by a base in order to produce the carboxylic acid. This reactivity makes 3-(6 - amino - pyridin - 3 - yl) acrylic acid ethyl ester a useful intermediate in organic synthesis for the preparation of more complex pyridine - based compounds.This reactivity makes 3- (6 - amino-pyridin- 3 yl)acrylic acid ethyl ester a useful organic synthesis intermediate for the preparation more complex pyridine-based compounds.

How is 3-(6-amino-pyridin-3-yl) acrylic acid ethyl ester synthesized?

The synthesis of 3-(6 - amino - pyridin - 3 - yl) acrylic acid ethyl ester can be achieved through the following general approach.The following general approach can be used to synthesize 3-(6- amino-pyridin- 3 -yl)acrylic acid ethyl ester.
1. Starting materials preparationStart materials preparation
Typically, 3 - bromo - 6 - aminopyridine is one of the key starting materials.Typically, the 3 -bromo -6 - aminopyridine serves as a key starting material. This can be synthesized from 3,6 - dibromopyridine through a selective amination reaction.This can be made from 3,6-dibromopyridine by a selective amination. For example, reacting 3,6 - dibromopyridine with an appropriate amine source, like ammonia in the presence of a suitable catalyst such as a palladium - based catalyst and a base.Reacting 3,6-dibromopyridine in the presence of an appropriate amine, such as ammonia, and a suitable catalyst, such as a palladium-based catalyst, is one example. The reaction conditions need to be carefully controlled to ensure the selective formation of 3 - bromo - 6 - aminopyridine.To ensure the formation of 3 – bromo – 6 – aminopyridine, it is important to carefully control the reaction conditions.

Ethyl acrylate is another essential starting material, which is commercially available.Ethyl Acrylate is a commercially available starting material.

2. Coupling reactionCoupling reaction
A common method to connect the pyridine moiety and the acrylic acid ethyl ester part is through a Heck reaction.Heck reaction is a common way to connect the pyridine and the acrylic acid ethyl esters. In this reaction, 3 - bromo - 6 - aminopyridine, ethyl acrylate, a palladium catalyst (such as palladium acetate), a ligand (like triphenylphosphine), and a base (such as triethylamine) are combined in an appropriate solvent, often an organic solvent like N,N - dimethylformamide (DMF) or toluene.In this reaction, the 3 -bromo -6 - aminopyridine and ethyl acrylicate are combined with a palladium catalyst (such as palladium oxide), a ligand, such as triphenylphosphine, and a base, such as triethylamine, in a suitable solvent, usually an organic solvent, like N,N-dimethylformamide (DMF), or toluene.
The reaction proceeds under heating, usually at a temperature in the range of 80 - 120 degC.The reaction is carried out under heating at a temperature between 80 and 120 degrees Celsius. The palladium catalyst activates the carbon - bromine bond in 3 - bromo - 6 - aminopyridine, and the ethyl acrylate undergoes an insertion reaction followed by a b - hydride elimination to form the desired 3-(6 - amino - pyridin - 3 - yl) acrylic acid ethyl ester.The palladium catalyst activates carbon-bromine bonds in 3 – bromo – 6 – aminopyridine. The ethyl-acrylate then undergoes a insertion reaction, followed by a b-hydride elimination, to form the desired 3- (6 - amino-pyridin – 3 -yl) acrylic acid ester.
During the reaction, proper control of reaction parameters such as reaction time, temperature, and the stoichiometry of reactants is crucial.It is important to control the reaction parameters, such as the reaction time, the temperature, and the stoichiometry. If the reaction temperature is too high, side reactions may occur, leading to the formation of by - products.If the temperature of the reaction is too high, it can cause side reactions, which may lead to the formation by-products. Also, the amount of catalyst and ligand can significantly affect the reaction rate and yield.The amount of catalysts and ligands can also have a significant impact on the yield and reaction rate.
3. Product isolation and purification3.
After the reaction is complete, the reaction mixture is usually cooled down.After the reaction has been completed, the reaction mixture will usually be cooled. The crude product can be isolated by methods such as extraction.Extraction is one way to isolate the crude product. For example, the reaction mixture can be poured into water and then extracted with an organic solvent like ethyl acetate.The reaction mixture can, for example, be poured in water and extracted with an organic solvent such as ethyl alcohol. The organic layer containing the product is then separated, dried over anhydrous sodium sulfate to remove water, and concentrated under reduced pressure.The organic layer containing product is separated, dried on anhydrous sodium chloride to remove water and concentrated under reduced pressurized.
The resulting crude product can be further purified by column chromatography.The crude product obtained can be purified further by column chromatography. A suitable stationary phase, such as silica gel, and an appropriate mobile phase, a mixture of solvents like hexane and ethyl acetate in a certain ratio, is used to separate the desired product from any remaining starting materials, by - products, and reaction impurities.The desired product is separated from the remaining starting materials, reaction impurities, and by-products using a stationary phase such as silica and a mobile phase consisting of a mixture like hexane with ethyl Acetate in a specific ratio. This purification step is important to obtain a high - purity 3-(6 - amino - pyridin - 3 - yl) acrylic acid ethyl ester.This step is crucial to obtain a high-purity 3-(6- amino-pyridin- 3 yl-) acrylic acid ethyl ester.

What are the safety precautions when handling 3-(6-amino-pyridin-3-yl) acrylic acid ethyl ester?

When handling 3-(6 - amino - pyridin - 3 - yl) acrylic acid ethyl ester, several safety precautions are necessary.Safety precautions must be taken when handling 3-(6- amino-pyridin- 3 -yl)acrylic acid ethyl ester.
First, personal protective equipment is crucial.Personal protective equipment is essential. Wear appropriate chemical - resistant gloves.Wear gloves that are resistant to chemicals. Nitrile gloves are often a good choice as they can provide a barrier against contact with the chemical.Nitrile gloves can be a good option as they provide a barrier to contact with the chemical. This helps prevent skin absorption, which could potentially lead to adverse health effects such as skin irritation, allergic reactions, or more serious systemic issues if the chemical enters the bloodstream.This can help prevent skin absorption which could lead to adverse health issues such as skin irritations, allergic reactions or more serious systemic problems if the chemical gets into the bloodstream.

Second, eye protection must be worn.Second, eye protection is required. Safety goggles or a face shield should be used.Safety goggles, or a face shield, should be worn. In case of any accidental splashing, these will safeguard the eyes from contact with the substance.These will protect the eyes in the event of an accidental splash. Chemicals in the eyes can cause severe damage, including burns, vision impairment, or even blindness.Chemicals in the eye can cause severe damage including blindness, vision impairment or even burns.

Ventilation is another key aspect.Ventilation is also important. Work in a well - ventilated area, preferably under a fume hood.Work in an area that is well-ventilated, preferably under the fume hood. 3-(6 - amino - pyridin - 3 - yl) acrylic acid ethyl ester may release vapors that could be harmful if inhaled.The 3-(6- amino-pyridin- 3 -yl) acrylic acids ethyl esters may release vapors which could be harmful to inhale. Adequate ventilation helps to dilute these vapors, reducing the risk of respiratory problems.Adequate ventilation can dilute these vapors and reduce the risk of respiratory issues. Inhalation of such chemicals can irritate the respiratory tract, cause coughing, shortness of breath, or in more severe cases, damage to the lungs.Inhaling these chemicals can cause irritation of the respiratory tract and lead to coughing, shortness or breath, and in severe cases, lung damage.

When storing the chemical, keep it in a cool, dry place away from sources of heat and ignition.Store the chemical in a cool and dry place, away from heat sources and ignition sources. This substance may be flammable or reactive under certain conditions.This substance could be flammable under certain conditions. Heat or an ignition source could potentially lead to a fire or explosion, endangering both the handler and the surrounding environment.Heat or an ignition source can lead to a fire, explosion or other dangerous situation.

Label all containers clearly.Label all containers clearly. Mark the container with the name of the chemical, any relevant hazard warnings such as toxicity, flammability, etc.Mark the container with any relevant warnings, such as toxicity or flammability. This ensures that anyone who comes into contact with the container is aware of the potential risks associated with the substance.This will ensure that anyone who comes in contact with the container knows the potential dangers associated with the substance.

In case of accidental exposure, have a plan in place.Prepare a plan for accidental exposure. For skin contact, immediately wash the affected area with plenty of water for at least 15 minutes.If skin contact occurs, wash the affected area immediately with plenty of water and for at least 15 min. Remove any contaminated clothing during this process.During this process, remove any contaminated clothing. If the chemical gets into the eyes, flush the eyes with copious amounts of water and seek immediate medical attention.If the chemical gets in the eyes, flush them with copious amounts water and seek immediate medical care. In case of inhalation, move to fresh air immediately and if breathing difficulties persist, call for emergency medical help.In the event of inhalation, get to fresh air as soon as possible. If breathing problems persist, seek emergency medical attention.

Finally, ensure that all handling procedures are carried out by trained personnel.Lastly, ensure that all handling is done by trained personnel. Workers should be educated about the properties of 3-(6 - amino - pyridin - 3 - yl) acrylic acid ethyl ester, the associated hazards, and the proper safety procedures to follow.Workers should be informed about the hazards and properties of 3-(6- amino-pyridin- 3 -yl)acrylic acid ethyl ester, as well as the safety procedures. This knowledge - based approach is fundamental to preventing accidents and protecting the well - being of those handling the chemical.This knowledge-based approach is essential to prevent accidents and protect the well-being of those who handle the chemical.