| product_name | Thiophene-2-acrylic acid |
| CAS_number | 32445-25-3 |
| formula | C7H6O2S |
| molar_mass | 154.19 g/mol |
| melting_point | 174-176 °C |
| boiling_point | None reported |
| density | None reported |
| solubility_in_water | Slightly soluble |
| refractive_index | None reported |
| appearance | White to off-white powder |
| flash_point | None reported |
| pKa | 4.11 |
| stability | Stable under normal temperatures and pressures |
What is Thiophene-2-acrylic acid?
Thiophene-2-acrylic acid, also known as
2-thienylacrylic acid or T2AA, is a chemical compound that belongs to the family of
thiophenes. It is a versatile building block in organic synthesis and is widely used in the
pharmaceutical and materials industries.
What are the key properties of
Thiophene-2-acrylic acid?
Thiophene-2-acrylic acid is a yellowish crystalline powder
with a molecular weight of 156.16 g/mol. It has a melting point of 145-147°C and is soluble
in organic solvents such as ethanol, acetone, and chloroform. It is light-sensitive and
should be stored in a dark and cool place.
What are the main applications of
Thiophene-2-acrylic acid?
Thiophene-2-acrylic acid is commonly used as a building
block in the synthesis of various pharmaceutical compounds, agrochemicals, and materials
such as conducting polymers. It is also used in the production of dyes, pigments, and
surfactants.
What are the benefits of using Thiophene-2-acrylic acid in organic
synthesis?
Thiophene-2-acrylic acid is a versatile compound that can undergo various
chemical reactions to yield a wide range of derivatives with different properties. It allows
for the introduction of the thiophene moiety into organic molecules, which can enhance their
biological or physical properties.
Can Thiophene-2-acrylic acid be used in
pharmaceutical applications?
Yes, Thiophene-2-acrylic acid is commonly used in the
pharmaceutical industry as a key intermediate in the synthesis of antiviral, antibacterial,
and anticancer drugs. Its unique chemical structure makes it a valuable building block for
designing new pharmaceutical compounds with improved efficacy.
How is
Thiophene-2-acrylic acid typically synthesized?
Thiophene-2-acrylic acid can be
synthesized through the Knoevenagel condensation reaction between thiophene-2-carbaldehyde
and malonic acid in the presence of a base catalyst. The reaction proceeds at relatively
mild conditions and produces high yields of the desired product.
What are the safety
considerations when handling Thiophene-2-acrylic acid?
Thiophene-2-acrylic acid
should be handled with care as it is a potentially hazardous substance. Personal protective
equipment such as gloves, goggles, and lab coats should be worn when working with this
compound. It should be stored and disposed of according to local regulations.
Are
there any alternative uses for Thiophene-2-acrylic acid outside of the pharmaceutical
industry?
Yes, Thiophene-2-acrylic acid has applications beyond the pharmaceutical
industry. It can be used in the synthesis of organic electronic materials, such as
light-emitting diodes (OLEDs) and organic photovoltaic cells (OPVs). It is also used in the
preparation of functionalized materials for sensors and catalysts.
What are the
future prospects for Thiophene-2-acrylic acid in the market?
Thiophene-2-acrylic acid
is expected to continue to be in high demand in the pharmaceutical and materials industries
due to its versatility and unique properties. As research into new drug candidates and
advanced materials continues to grow, the demand for this compound is likely to
increase.
In conclusion, Thiophene-2-acrylic acid is a valuable compound with a wide
range of applications in organic synthesis, pharmaceuticals, and materials science. Its
unique properties and versatility make it an essential building block for the development of
new drugs and advanced materials.
