| product_name | Thiophene-2-acrylic acid |
| CAS_number | 32445-25-3 |
| formula | C7H6O2S |
| molar_mass | 154.19 g/mol |
| melting_point | 174-176 °C |
| boiling_point | None reported |
| density | None reported |
| solubility_in_water | Slightly soluble |
| refractive_index | None reported |
| appearance | White to off-white powder |
| flash_point | None reported |
| pKa | 4.11 |
| stability | Stable under normal temperatures and pressures |
What is Thiophene-2-acrylic acid?
Thiophene-2-acrylic acid, also known as 2-thienylacrylic acid or T2AA, is a chemical compound that belongs to the family of thiophenes. It is a versatile building block in organic synthesis and is widely used in the pharmaceutical and materials industries.
What are the key properties of Thiophene-2-acrylic acid?
Thiophene-2-acrylic acid is a yellowish crystalline powder with a molecular weight of 156.16 g/mol. It has a melting point of 145-147°C and is soluble in organic solvents such as ethanol, acetone, and chloroform. It is light-sensitive and should be stored in a dark and cool place.
What are the main applications of Thiophene-2-acrylic acid?
Thiophene-2-acrylic acid is commonly used as a building block in the synthesis of various pharmaceutical compounds, agrochemicals, and materials such as conducting polymers. It is also used in the production of dyes, pigments, and surfactants.
What are the benefits of using Thiophene-2-acrylic acid in organic synthesis?
Thiophene-2-acrylic acid is a versatile compound that can undergo various chemical reactions to yield a wide range of derivatives with different properties. It allows for the introduction of the thiophene moiety into organic molecules, which can enhance their biological or physical properties.
Can Thiophene-2-acrylic acid be used in pharmaceutical applications?
Yes, Thiophene-2-acrylic acid is commonly used in the pharmaceutical industry as a key intermediate in the synthesis of antiviral, antibacterial, and anticancer drugs. Its unique chemical structure makes it a valuable building block for designing new pharmaceutical compounds with improved efficacy.
How is Thiophene-2-acrylic acid typically synthesized?
Thiophene-2-acrylic acid can be synthesized through the Knoevenagel condensation reaction between thiophene-2-carbaldehyde and malonic acid in the presence of a base catalyst. The reaction proceeds at relatively mild conditions and produces high yields of the desired product.
What are the safety considerations when handling Thiophene-2-acrylic acid?
Thiophene-2-acrylic acid should be handled with care as it is a potentially hazardous substance. Personal protective equipment such as gloves, goggles, and lab coats should be worn when working with this compound. It should be stored and disposed of according to local regulations.
Are there any alternative uses for Thiophene-2-acrylic acid outside of the pharmaceutical industry?
Yes, Thiophene-2-acrylic acid has applications beyond the pharmaceutical industry. It can be used in the synthesis of organic electronic materials, such as light-emitting diodes (OLEDs) and organic photovoltaic cells (OPVs). It is also used in the preparation of functionalized materials for sensors and catalysts.
What are the future prospects for Thiophene-2-acrylic acid in the market?
Thiophene-2-acrylic acid is expected to continue to be in high demand in the pharmaceutical and materials industries due to its versatility and unique properties. As research into new drug candidates and advanced materials continues to grow, the demand for this compound is likely to increase.
In conclusion, Thiophene-2-acrylic acid is a valuable compound with a wide range of applications in organic synthesis, pharmaceuticals, and materials science. Its unique properties and versatility make it an essential building block for the development of new drugs and advanced materials.