| product_name | trans-3-(3-thienyl)acrylic acid |
| CAS_number | 6283-41-0 |
| formula | C7H6O2S |
| molar_mass | 154.19 g/mol |
| density | 1.309 g/cm³ |
| boiling_point | 338.1 °C |
| melting_point | 146-148 °C |
| appearance | solid |
| solubility | Slightly soluble in water |
| refractive_index | n20/D 1.581 |
| pKa | 3.82 |
| stability | Stable under recommended storage conditions |
| flash_point | 127.4 °C |
| vapor_pressure | 0.000208 mmHg at 25 °C |
What is trans-3-(3-thienyl)acrylic acid and what are its uses?
Trans-3-(3-thienyl)acrylic acid, also known as thiophene acrylic acid, is a key intermediate in the synthesis of various pharmaceuticals, agrochemicals, and functional materials. It is a versatile compound with diverse applications in industries such as pharmaceuticals, agriculture, and materials science.
Can trans-3-(3-thienyl)acrylic acid be used in pharmaceutical applications?
Yes, trans-3-(3-thienyl)acrylic acid is commonly used as a building block in the synthesis of pharmaceutical compounds. Its unique structural properties make it a valuable precursor in the production of various pharmaceutical ingredients, including anti-inflammatory drugs, antibacterial agents, and anticancer medications.
How is trans-3-(3-thienyl)acrylic acid synthesized?
Trans-3-(3-thienyl)acrylic acid can be synthesized through several methods, including the Wittig reaction, Grignard reaction, or Heck reaction. The most common route involves the palladium-catalyzed coupling of 3-bromo-thiophene with ethyl acetoacetate followed by acid hydrolysis to obtain trans-3-(3-thienyl)acrylic acid in high yields.
What are the key properties of trans-3-(3-thienyl)acrylic acid that make it suitable for various applications?
Trans-3-(3-thienyl)acrylic acid possesses unique chemical and physical properties that make it highly attractive for use in different industries. Its conjugated structure, high reactivity, and thermal stability contribute to its versatility in applications such as drug discovery, polymer synthesis, and materials science.
Is trans-3-(3-thienyl)acrylic acid environmentally friendly?
Trans-3-(3-thienyl)acrylic acid is considered to be environmentally friendly due to its low toxicity and biodegradability. Its use in pharmaceutical and agrochemical applications is regulated to ensure minimal impact on the environment, making it a sustainable choice for various industries.
What are the risks associated with handling trans-3-(3-thienyl)acrylic acid?
Although trans-3-(3-thienyl)acrylic acid is generally considered safe to use, proper precautions should be taken when handling this compound. It is important to wear appropriate personal protective equipment, such as gloves and goggles, and work in a well-ventilated area to avoid any potential skin contact or inhalation of the product.
What quality standards should trans-3-(3-thienyl)acrylic acid meet for industrial applications?
Trans-3-(3-thienyl)acrylic acid used in industrial applications must meet strict quality standards to ensure product performance and safety. These standards may include purity levels, moisture content, and impurity profiles that comply with industry regulations and customer specifications.
Can trans-3-(3-thienyl)acrylic acid be customized for specific applications?
Yes, trans-3-(3-thienyl)acrylic acid can be customized to meet the specific requirements of different applications. Manufacturers can tailor the synthesis process, purity levels, and formulations of the compound to suit the needs of customers in pharmaceutical, agricultural, or materials science industries.
What are the future prospects for trans-3-(3-thienyl)acrylic acid in the market?
The future prospects for trans-3-(3-thienyl)acrylic acid are promising, with growing demand for customized compounds in pharmaceutical and materials science industries. As research and development in these fields continue to expand, trans-3-(3-thienyl)acrylic acid is likely to play a crucial role in the synthesis of novel drugs, innovative materials, and specialty chemicals.