| product_name | trans-3-(3-thienyl)acrylic acid |
| CAS_number | 6283-41-0 |
| formula | C7H6O2S |
| molar_mass | 154.19 g/mol |
| density | 1.309 g/cm³ |
| boiling_point | 338.1 °C |
| melting_point | 146-148 °C |
| appearance | solid |
| solubility | Slightly soluble in water |
| refractive_index | n20/D 1.581 |
| pKa | 3.82 |
| stability | Stable under recommended storage conditions |
| flash_point | 127.4 °C |
| vapor_pressure | 0.000208 mmHg at 25 °C |
What is trans-3-(3-thienyl)acrylic acid and what are its
uses?
Trans-3-(3-thienyl)acrylic acid, also known as thiophene acrylic acid, is a key
intermediate in the synthesis of various pharmaceuticals, agrochemicals, and functional
materials. It is a versatile compound with diverse applications in industries such as
pharmaceuticals, agriculture, and materials science.
Can trans-3-(3-thienyl)acrylic
acid be used in pharmaceutical applications?
Yes, trans-3-(3-thienyl)acrylic acid is
commonly used as a building block in the synthesis of pharmaceutical compounds. Its unique
structural properties make it a valuable precursor in the production of various
pharmaceutical ingredients, including anti-inflammatory drugs, antibacterial agents, and
anticancer medications.
How is trans-3-(3-thienyl)acrylic acid
synthesized?
Trans-3-(3-thienyl)acrylic acid can be synthesized through several
methods, including the Wittig reaction, Grignard reaction, or Heck reaction. The most common
route involves the palladium-catalyzed coupling of 3-bromo-thiophene with ethyl acetoacetate
followed by acid hydrolysis to obtain trans-3-(3-thienyl)acrylic acid in high
yields.
What are the key properties of trans-3-(3-thienyl)acrylic acid that make it
suitable for various applications?
Trans-3-(3-thienyl)acrylic acid possesses unique
chemical and physical properties that make it highly attractive for use in different
industries. Its conjugated structure, high reactivity, and thermal stability contribute to
its versatility in applications such as drug discovery, polymer synthesis, and materials
science.
Is trans-3-(3-thienyl)acrylic acid environmentally
friendly?
Trans-3-(3-thienyl)acrylic acid is considered to be environmentally
friendly due to its low toxicity and biodegradability. Its use in pharmaceutical and
agrochemical applications is regulated to ensure minimal impact on the environment, making
it a sustainable choice for various industries.
What are the risks associated with
handling trans-3-(3-thienyl)acrylic acid?
Although trans-3-(3-thienyl)acrylic acid is
generally considered safe to use, proper precautions should be taken when handling this
compound. It is important to wear appropriate personal protective equipment, such as gloves
and goggles, and work in a well-ventilated area to avoid any potential skin contact or
inhalation of the product.
What quality standards should trans-3-(3-thienyl)acrylic
acid meet for industrial applications?
Trans-3-(3-thienyl)acrylic acid used in
industrial applications must meet strict quality standards to ensure product performance and
safety. These standards may include purity levels, moisture content, and impurity profiles
that comply with industry regulations and customer specifications.
Can
trans-3-(3-thienyl)acrylic acid be customized for specific applications?
Yes,
trans-3-(3-thienyl)acrylic acid can be customized to meet the specific requirements of
different applications. Manufacturers can tailor the synthesis process, purity levels, and
formulations of the compound to suit the needs of customers in pharmaceutical, agricultural,
or materials science industries.
What are the future prospects for
trans-3-(3-thienyl)acrylic acid in the market?
The future prospects for
trans-3-(3-thienyl)acrylic acid are promising, with growing demand for customized compounds
in pharmaceutical and materials science industries. As research and development in these
fields continue to expand, trans-3-(3-thienyl)acrylic acid is likely to play a crucial role
in the synthesis of novel drugs, innovative materials, and specialty chemicals.
